Pulmonary Macrophage Transplantation Therapy ofHereditary Pulmonary Alveolar Proteinosis
نویسندگان
چکیده
منابع مشابه
Granulocyte macrophage colony stimulating factor therapy for pulmonary alveolar proteinosis.
We report a case of 58 year old female diagnosed with Pulmonary Alveolar Proteinosis (PAP) with recurrence of PAP after 5 repeated whole lung lavage, responding to subcutaneous injections of Granulocyte Macrophage Colony Stimulating Factor therapy (GM-CSF). Thus indicating that GM-CSF therapy is a promising alternative in those requiring repeated whole lung lavage
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Idiopathic pulmonary alveolar proteinosis is presumed to be an autoimmune disorder that may lead to pulmonary insufficiency. However, steroids do not appear to be effective and the standard of therapy is whole-lung lavage. We report the first case of successful therapy with rituximab, which addresses the pathogenic mechanism of pulmonary alveolar proteinosis.
متن کاملPulmonary Alveolar Proteinosis
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متن کاملPulmonary alveolar proteinosis.
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary disease characterised by alveolar accumulation of surfactant. It may result from mutations in surfactant proteins or granulocyte macrophage-colony stimulating factor (GM-CSF) receptor genes, it may be secondary to toxic inhalation or haematological disorders, or it may be auto-immune, with anti-GM-CSF antibodies blocking activation of alv...
متن کاملPulmonary alveolar proteinosis.
Pulmonary alveolar proteinosis is a rare cause of respiratory distress in neonates. We present a 4 month old infant who presented with progressive respiratory distress since birth and failure to thrive. He was initially treated as a case of diffuse alveolar disease but on open lung biopsy was diagnosed as pulmonary alveolar proteinosis. The child expired at 7 months of age.
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ژورنال
عنوان ژورنال: The Keio Journal of Medicine
سال: 2015
ISSN: 0022-9717,1880-1293
DOI: 10.2302/kjm.64-002-abst